1.0% All-Trans Retinol
A high-strength retinol level selected to support visible skin renewal, texture refinement and tone clarity in users already accustomed to retinoids.
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A high-strength retinol gel combining precision delivery, Plant Exosome technology and clinical-grade performance for visibly smoother, firmer, more refined skin.
Reti-XO Gel pairs 1.0% All-Trans Retinol with plant-derived exosomes in a precision gel matrix designed for slower, more controlled absorption. Developed for experienced retinol users, it supports visible renewal, smoother texture, improved tone clarity and firmer-looking skin while prioritizing tolerability and consistency.
Dr. Alster's approach is to choose strong actives, control their delivery, protect the barrier and stay consistent. Reti-XO Gel reflects that philosophy by pairing 1.0% All-Trans Retinol with a controlled gel matrix designed for gradual absorption rather than an immediate release of the active.
The formula is especially relevant for experienced retinol users seeking targeted correction in areas such as the jawline, chin, forehead and lower face, where congestion, textural irregularity or visible laxity may be more apparent.
A high-strength retinol level selected to support visible skin renewal, texture refinement and tone clarity in users already accustomed to retinoids.
The gel-based system is designed for slower, more controlled penetration, helping improve tolerability and making targeted application easier to control.
Plant-derived exosomes support skin communication during renewal, while phospholipids and antioxidants help support barrier integrity as skin adapts to the active.
If sensitivity occurs, begin 2–3 nights per week and increase frequency as tolerated. Avoid layering Reti-XO Gel with exfoliating acids or additional retinoids in the same routine; pair it with calming, barrier-supportive products instead.
Apply a pea-sized amount to clean, dry skin in the evening. For those who experience sensitivity, begin 2–3 nights per week and increase frequency as tolerated. Always follow with a moisturizer and use daily SPF while using this product.
Mild dryness or flaking may occur initially as skin acclimates to a high-strength retinol. The formula is designed for experienced retinol users; those who are new to retinol or have reactive skin should consider a lower-strength option.
Reti-XO Gel may be incorporated after professional treatments when directed by your provider and once the skin is ready to resume active renewal.
Isododecane, Polysilicone-23, Cyclopentasiloxane, Water, Phospholipids, Reti-XO Cellular Renewal Complex™, Pentylene Glycol, Lecithin, All-Trans Retinol, Polysorbate 20, Alcohol, Potassium Phosphate, Tocopherol, Ascorbyl Palmitate, BHT, BHA, Tocopheryl Acetate.
Apply a pea-sized amount to clean, dry skin in the evening. For those who experience sensitivity, begin 2–3 nights per week and increase frequency as tolerated. Always follow with a moisturizer and use daily SPF while using this product.
Skin elasticity and conditions for firmer, smoother, healthier-looking skin.
PM • All Skin Types
• 1.0% All-Trans Retinol supports visible skin renewal, texture refinement, and tone clarity.
• Plant-Derived Exosomes help optimize cellular communication and enhance skin recovery.
• Gel-Based Delivery System allows controlled absorption for improved tolerance and precision.
• Phospholipids & Antioxidants support barrier integrity during active renewal.
• Clinically Inspired Formulation ideal for experienced retinol users and professional protocols.
Isododecane, Polysilicone-23, Cyclopentasiloxane, Water, Phospholipids, Reti-XO Cellular Renewal ComplexTM, Pentylene Glycol, Lecithin, All-Trans Retinol, Polysorbate 20, Alcohol, Potassium Phosphate, Tocopherol, Ascorbyl Palmitate, BHT, BHA, Tocopheryl Acetate.
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Frequently asked questions about Reti-XO Gel
I just started using Reti-XO a couple months ago and so far I think it's actually helped with my fine lines. Only reason I didn't give it 5 stars is because I haven't used it for very long.